Update on Neurodevelopment and Schizophrenia

Micronutrients and neurodevelopment: An update.

Micronutrients make up the central nervous system structure and play major functional roles: they stimulate nerve cell development, migration, and differentiation. The goal of this study is to review the scientific literature regarding the role of micronutrients in infant brain structure and function. Thus, we aim at providing pediatricians with knowledge on the importance of introducing all nu...

Impact of anaesthetics and surgery on neurodevelopment: an update.

Accumulating preclinical and clinical evidence suggests the possibility of neurotoxicity from neonatal exposure to general anaesthetics. Here, we review the weight of the evidence from both human and animal studies and discuss the putative mechanisms of injury and options for protective strategies. Our review identified 55 rodent studies, seven primate studies, and nine clinical studies of inte...

Bridging pharmacology and neurodevelopment in schizophrenia.

At the beginning of the 20th century, when neuropathologists had long searched without success for the neural basis of schizophrenia, this field was called a ‘graveyard for neuropathologists ’. This disappointment opened the door for psychiatrists to focus on psychopathology. The discovery of antipsychotic agents in the 1950s provided a clue to understanding the pathology of this difficult dise...

Common Gene Variants in Schizophrenia Susceptibility with Focus on Neurodevelopment

Prenatal Exposures to Environmental Chemicals and Children's Neurodevelopment: An Update

This review surveys the recent literature on the neurodevelopmental impacts of chemical exposures during pregnancy. The review focuses primarily on chemicals of recent concern, including phthalates, bisphenol-A, polybrominated diphenyl ethers, and perfluorinated compounds, but also addresses chemicals with longer histories of investigation, including air pollutants, lead, methylmercury, mangane...